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Artificial Cancer-Killing Virus

It is the genome of an oncolytic virus, it is 34,000 base pairs long, and it is 100% artificial. It’s important because it not only has immediate application in studies of canine cancer, it also promises to inform the development of human therapies. In these human therapies, artificial viruses could be customized to such an extent, that they could qualify as personalized anticancer therapeutics.  It is not the first time that oncolytic viruses has engineered but earlier virus like Herpes simplex and Oncorine(H101) are also being used.  The virus in question in sCAV2, a conditionally replicative adenovirus (CRAd) that can target and kill tumor cells while sparing healthy cells. It was synthesized by scientists affiliated with Gen9, who worked in concert with scientists representing Autodesk and Auburn University. At Auburn, scientists led by Bruce Smith, V.M.D., Ph.D., intend to use the synthetic virus to evaluate therapeutic treatments in dogs with osteosarcoma, a
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Autophagy: A Nobel Prize Topic

        Introduction The word autophagy is derived from Greek words “auto” meaning self and “phagy” meaning eating. Autophagy is a normal physiological process in the body that deals with destruction of cells in the body. It maintains homeostasis or normal functioning by protein degradation and turnover of the destroyed cell organelles for new cell formation. During cellular stress the process of Autophagy is upscaled and increased. Cellular stress is caused when there is deprivation of nutrients and/or growth factors. Thus Autophagy may provide an alternate source of intracellular building blocks and substrates that may generate energy to enable continuous cell survival. History Autophagy has been known for over 50 years but its fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi's paradigm-shifting research in the 1990's. For his discoveries, he is awarded this year's Nobel Prize in physiology or medicine.

Promising Gene Therapy For Sicker Cell Anemia

A new engineered gene therapy virus, inserted into blood stem cells and then transplanted into mice with sickle cell disease, markedly reduced red blood cell damage according to the study “Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype,” published in the Journal of Clinical Investigation. A clinical gene therapy trial is expected in the coming year in which researchers will use a gene manipulated harmless virus to prevent the “sickling” of red blood cells. The new gene therapy is based on research going back to the 1980s which revealed that people with a milder form of sickle cell disease carried a fetal form of hemoglobin. This form is present in the human fetus and normally tapers off after birth. It differs most from “adult” (beta) hemoglobin because it is able to bind oxygen to a larger extent and is not seen to “sickle”. In later studies, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center researchers showed t

The Peptide Polymer Could Replace The Antibiotic

                   Introduction Antibiotics are the group of medicine or drug which is use to treat the infections caused by the bacteria ( infections like respiratory tract infection,urinary tract infection, skin infection etc.) Common infections with treated Antibiotics  As the students of life sciences knows very about Penicillin( now one the major class of Antibiotics) is the first antibiotics which is Discovered by the Alexander Flaming in 1928 and It is the most known antibiotic in the history. Infection - Antibiotics  1.Acne -Amoxicillin 2.Bronchitis -Doxycycline 3.Conjunctivitis -Cephalexin 4.Otitis media-ciprofloxacin 5.Sexually Transmitted Diseases (STD’s)-Clindamycin 6.Skin or soft Tissue infection -Metronidazole 7.Streptococcal Pharyngitis-Azithromycin 8.Travelers diarrhea -Sulfamethoxazole /trimethoprim 9.Upper Respiratory tract infection -Amoxicillin /Clavulanate 10.Urinary tract infection -Levofloxacin Problem with Antibiotics   

The New Blood Group 'INRA'

Usually there are 4 or 5 blood groups to be known namely A,B,O,AB and rarely Bombay or HH blood group. The Bombay blood group are named after its discovery in the city Bombay (now called Mumbai city)discover by the Dr. Y.M. Bhende in 1952  and this is the first time India become a parent of the new and rarest type of blood group. It is obvious,Bomby blood group is the first blood group found in India but not the least "because discovery never stops" This saying fix here perfectly,A person with new & rare blood group is found in Lok Samparn Raktdan laboratory, Surat, Gujarat. The person’s blood group doesn’t match with any other A, B, O, AB and also Bombay Blood Group or also called as HH Blood Group. The new blood group is named as INRA; the first 2 letters represent India (IN) & the next two name of the person (RA). INRA blood group is identified for the first time when the person visited for donating blood in Blood Camp. The blood sample was prev

The Discovery Of Sixth DNA Base

       Introduction an article published in Cell by Manel Esteller, director of the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, describes the possible existence of a sixth DNA base, the methyl-adenine (mA), which also help determine the epigenome and would therefore be key in the life of the cells. DNA (deoxyribonucleic acid) is the main component of our genetic material. It is formed by combining four parts: A, C, G and T (adenine, cytosine, guanine and thymine), called bases of DNA combine in thousands of possible sequences to provide the genetic variability that enables the wealth of aspects and functions of living beings. History Two more bases : the Methyl- cytosine and Methyl-adenine In the early 80s, to these four "classic" bases of DNA was added a fifth: the methyl-cytosine (mC) derived from cytosine. And it wa

An Plant With Ability To Kill 14 Types Of Cancers And 13 Kinds Of Infections

                                                                      INTRODUCTION                                   The immense potential of plant were never underestimated nature gave us infinite number of plants which cure almost any disease.On  the other hand the synthetic or the pharmaceutical false promises to cure certain  disease like cancer make the irrelevant expectation  but whereas the natural reme dies have no side effect,safe,inexpensive, and delicious.Many spices are attaining recognition for being quite literally, 'Life Saving' which is one reason why, in ancient times, many were worth their weight in gold. This time around, the health benefits of ancient 'folk remedies' like garlic are being confirmed by straight laced men and women in lab coats which,when it comes to the conventional medical establishment, blighted as it is by the epistemological (theory of knowledge or opinion or believe) disease known as myopia is considered th