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The Peptide Polymer Could Replace The Antibiotic



                  

Introduction

Antibiotics are the group of medicine or drug which is use to treat the infections caused by the bacteria ( infections like respiratory tract infection,urinary tract infection, skin infection etc.)

Common infections with treated Antibiotics 

As the students of life sciences knows very about Penicillin( now one the major class of Antibiotics) is the first antibiotics which is Discovered by the Alexander Flaming in 1928 and It is the most known antibiotic in the history.



 Infection -Antibiotics 
1.Acne -Amoxicillin
2.Bronchitis -Doxycycline
3.Conjunctivitis -Cephalexin
4.Otitis media-ciprofloxacin
5.Sexually Transmitted Diseases (STD’s)-Clindamycin
6.Skin or soft Tissue infection -Metronidazole
7.Streptococcal Pharyngitis-Azithromycin
8.Travelers diarrhea -Sulfamethoxazole /trimethoprim
9.Upper Respiratory tract infection -Amoxicillin /Clavulanate
10.Urinary tract infection -Levofloxacin


Problem with Antibiotics 
 
The actual principle of the antibiotics is that antibiotics degrade the cell wall of the bacteria which mean to kill the bacteria but the exposure of the numerous Antibiotics make bacteria to resist /mutate Antibiotics. These mutated bacteria are known as 'superbugs'. "It is estimated that the rise of superbugs will cause up to 10 million deaths a year by 2050. In addition, there have only been one or two new antibiotics developed in the last 30 years," researcher said.


Cures from the recent research 

 Scientists claim to have developed tiny, star-shaped molecules which may effectively wipe out deadly bacteria that can no longer be killed by current antibiotics. The study holds promise for a new treatment method against antibiotic-resistant bacteria, commonly known as superbugs, researchers said.
The star-shaped structures, are short chains of proteins called 'peptide polymers', and were created by a team from the University of Melbourne School of Engineering.

What is Peptide Polymer?

The gram negative bacteria are hard to kill specially when they are resistant to drug. So the researchers design star-shaped antimicrobial nanoparticles made of amino acids. The molecules killed several common Gram-negative pathogens in culture, and cleared infections in mice caused by 

Acinetobacter baumannii, which is resistant to several antibiotics. When cultured with sublethal concentrations of the nanoparticles for 24 days, A. baumannii did not grow resistant over 600 generations.
The nanoparticles hit multiple targets — disrupting the bacterial outer membrane and the exchange of ions, and inducing pathways for cell death — and are likely to be more stable and less toxic than most antimicrobials under development.

My opinion 

This is probably the biggest and curious research topic that we all waiting for because more then prescribed antibiotics is dangerous to patient's gut flora. I am sure  research Complete their trial soon and  brought the new 'Peptide Polymer' in the market so as more as patient can use it and make their life more prosperous.


Source of the story: Times of India(news paper)
                                   journal Nature    microbiology
                                  Drugs.com    
                                 www.wsj.com

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