Skip to main content

The Peptide Polymer Could Replace The Antibiotic



                  

Introduction

Antibiotics are the group of medicine or drug which is use to treat the infections caused by the bacteria ( infections like respiratory tract infection,urinary tract infection, skin infection etc.)

Common infections with treated Antibiotics 

As the students of life sciences knows very about Penicillin( now one the major class of Antibiotics) is the first antibiotics which is Discovered by the Alexander Flaming in 1928 and It is the most known antibiotic in the history.



 Infection -Antibiotics 
1.Acne -Amoxicillin
2.Bronchitis -Doxycycline
3.Conjunctivitis -Cephalexin
4.Otitis media-ciprofloxacin
5.Sexually Transmitted Diseases (STD’s)-Clindamycin
6.Skin or soft Tissue infection -Metronidazole
7.Streptococcal Pharyngitis-Azithromycin
8.Travelers diarrhea -Sulfamethoxazole /trimethoprim
9.Upper Respiratory tract infection -Amoxicillin /Clavulanate
10.Urinary tract infection -Levofloxacin


Problem with Antibiotics 
 
The actual principle of the antibiotics is that antibiotics degrade the cell wall of the bacteria which mean to kill the bacteria but the exposure of the numerous Antibiotics make bacteria to resist /mutate Antibiotics. These mutated bacteria are known as 'superbugs'. "It is estimated that the rise of superbugs will cause up to 10 million deaths a year by 2050. In addition, there have only been one or two new antibiotics developed in the last 30 years," researcher said.


Cures from the recent research 

 Scientists claim to have developed tiny, star-shaped molecules which may effectively wipe out deadly bacteria that can no longer be killed by current antibiotics. The study holds promise for a new treatment method against antibiotic-resistant bacteria, commonly known as superbugs, researchers said.
The star-shaped structures, are short chains of proteins called 'peptide polymers', and were created by a team from the University of Melbourne School of Engineering.

What is Peptide Polymer?

The gram negative bacteria are hard to kill specially when they are resistant to drug. So the researchers design star-shaped antimicrobial nanoparticles made of amino acids. The molecules killed several common Gram-negative pathogens in culture, and cleared infections in mice caused by 

Acinetobacter baumannii, which is resistant to several antibiotics. When cultured with sublethal concentrations of the nanoparticles for 24 days, A. baumannii did not grow resistant over 600 generations.
The nanoparticles hit multiple targets — disrupting the bacterial outer membrane and the exchange of ions, and inducing pathways for cell death — and are likely to be more stable and less toxic than most antimicrobials under development.

My opinion 

This is probably the biggest and curious research topic that we all waiting for because more then prescribed antibiotics is dangerous to patient's gut flora. I am sure  research Complete their trial soon and  brought the new 'Peptide Polymer' in the market so as more as patient can use it and make their life more prosperous.


Source of the story: Times of India(news paper)
                                   journal Nature    microbiology
                                  Drugs.com    
                                 www.wsj.com

Comments

Post a Comment

Popular posts from this blog

The New Blood Group 'INRA'

Usually there are 4 or 5 blood groups to be known namely A,B,O,AB and rarely Bombay or HH blood group. The Bombay blood group are named after its discovery in the city Bombay (now called Mumbai city)discover by the Dr. Y.M. Bhende in 1952  and this is the first time India become a parent of the new and rarest type of blood group. It is obvious,Bomby blood group is the first blood group found in India but not the least "because discovery never stops" This saying fix here perfectly,A person with new & rare blood group is found in Lok Samparn Raktdan laboratory, Surat, Gujarat. The person’s blood group doesn’t match with any other A, B, O, AB and also Bombay Blood Group or also called as HH Blood Group. The new blood group is named as INRA; the first 2 letters represent India (IN) & the next two name of the person (RA). INRA blood group is identified for the first time when the person visited for donating blood in Blood Camp. The blood sample was prev
Post a Comment
Read more

Autophagy: A Nobel Prize Topic

        Introduction The word autophagy is derived from Greek words “auto” meaning self and “phagy” meaning eating. Autophagy is a normal physiological process in the body that deals with destruction of cells in the body. It maintains homeostasis or normal functioning by protein degradation and turnover of the destroyed cell organelles for new cell formation. During cellular stress the process of Autophagy is upscaled and increased. Cellular stress is caused when there is deprivation of nutrients and/or growth factors. Thus Autophagy may provide an alternate source of intracellular building blocks and substrates that may generate energy to enable continuous cell survival. History Autophagy has been known for over 50 years but its fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi's paradigm-shifting research in the 1990's. For his discoveries, he is awarded this year's Nobel Prize in physiology or medicine.
Post a Comment
Read more

Artificial Cancer-Killing Virus

It is the genome of an oncolytic virus, it is 34,000 base pairs long, and it is 100% artificial. It’s important because it not only has immediate application in studies of canine cancer, it also promises to inform the development of human therapies. In these human therapies, artificial viruses could be customized to such an extent, that they could qualify as personalized anticancer therapeutics.  It is not the first time that oncolytic viruses has engineered but earlier virus like Herpes simplex and Oncorine(H101) are also being used.  The virus in question in sCAV2, a conditionally replicative adenovirus (CRAd) that can target and kill tumor cells while sparing healthy cells. It was synthesized by scientists affiliated with Gen9, who worked in concert with scientists representing Autodesk and Auburn University. At Auburn, scientists led by Bruce Smith, V.M.D., Ph.D., intend to use the synthetic virus to evaluate therapeutic treatments in dogs with osteosarcoma, a
Post a Comment
Read more